The 2021 Honda Odyssey has achieved the highest award from the Insurance Institute for Highway Safety, Top Safety Pick+. Although the Odyssey is not a new generation for 2021, it does benefit from several changes, including newly standard active-safety features and new LED headlamps that appear across the lineup.

Previously, the 2020 Odyssey performed well in all six crash tests, achieving the highest, Good, score in all six. It's halogen headlamps, however, were rated Marginal and Poor (depending on the version). And its collision-avoidance system had not been tested. The 2021 Odyssey has LED headlamps as standard, and they earned an Acceptable score. Additionally, the Odyssey's collision-avoidance system is now included on all trims, and it earned a Superior rating in vehicle-to-vehicle and vehicle-to-pedestrian tests. The Odyssey also received a Good+ score for LATCH ease of use — the best among minivans — although that is not part of the criteria for a TSP+ award.