Princess Mako will visit Peru and Bolivia in July to attend ceremonies marking the 120th anniversary of the arrival of the first Japanese immigrants to those countries.
Princess Mako is the eldest daughter of Crown Prince and Princess Akishino.
The Imperial Household Agency says Princess Mako is scheduled to travel to the South American countries from July 9 to 22.
Princess Mako's trip will begin in Lima, the capital of Peru, which she will reach via Houston in the US. She will give an address at a ceremony to commemorate the anniversary and meet Peruvians of Japanese descent.
She has been invited to visit President Martin Vizcarra.
Her travel schedule in Peru also includes touring Machu Picchu, an ancient Inca city that is a World Heritage site. Princess Mako will hear from locals about the contributions that Japanese immigrants made in the area.
In Bolivia, the Princess will attend relevant ceremonies and visit places where immigrants settled.
About 100,000 people of Japanese descent are reported to live in Peru. That's the third-largest such population in the world. Bolivia is estimated to be home to more than 10,000 people of Japanese origin.
It will be the fifth official overseas visit for Princess Mako. Last year she went to Brazil to attend a ceremony marking the 110th anniversary of Japanese immigration there.